Lewis Base Activation of Lewis Acids. Vinylogous Aldol Reactions
Scott E. Denmark* and Gregory L. Beutner
*Roger Adams Laboratory, Department of Chemistry, University of Illinois, Urbana, Illinois 61801, Email: denmarkscs.uiuc.edu
S. E. Denmark, G. L. Beutner, J. Am. Chem. Soc., 2003, 125, 7800-7801.
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A highly regioselective vinylogous aldol reaction provides δ-hydroxy enones for a variety of aldehyde and dienol ether structures in good yields, excellent enantioselectivities, and in some cases excellent anti diastereoselectivities in the presence of SiCl4 and the catalytic action of a chiral phosphoramide.
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α,β-unsaturated compounds, homoallylic alcohols, Mukayiama Aldol Addition