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A General Procedure for the Synthesis of 2-Substituted Pyrimidine-5-Carboxylic Esters

Pavel Zhichkin, David J. Fairfax*, Shane A. Eisenbeis

*lbany Molecular Research Inc., 21 Corporate Circle, PO Box 15098, Albany, NY 12212, USA, Email: DavidFalbmolecular.com

P. Zhichkin, D. J. Fairfax, S. A. Eisenbein, Synthesis, 2002, 720-722.

DOI: 10.1055/s-2002-25767


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Abstract

A method for the synthesis of 2-substituted pyrimidine-5-carboxylic esters is described. The sodium salt of 3,3-dimethoxy-2-methoxycarbonylpropen-1-ol has been found to react with a variety of amidinium salts to afford the corresponding 2-substituted pyrimidine-5-carboxylic esters.

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Key Words

heterocycles, pyrimidines, condensation, amidinium salt, esters


ID: J66-Y2002-1490