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2-Acylpyridazin-3-ones: Novel Mild and Chemoselective Acylating Agents for Amines

Young-Jin Kang, Hyun-A Chung, Jeum-Jong Kim, Yong-Jin Yoon*

*Department of Chemistry and Research Institute of Natural Sciences, Gyeongsang National University, Chinju 660-701, Korea, Email:

Y.-J. Kang, H.-A Chung, J.-J. Kim, Y.-J. Yoon, Synthesis, 2002, 733-738.

DOI: 10.1055/s-2002-25760


2-Acyl-4,5-dichloropyridazin-3-ones served as stable, convenient and chemoselective N-acylating reagents for amines under neutral conditions.

see article for more examples

Phenyl 4,5-Dichloro-6-Oxopyridazine-1(6H)-Carboxylate as Carbonyl Source: Facile and Selective Synthesis of Carbamates and Ureas under Mild Conditions

H.-G. Lee, M.-J. Kim, S.-E. Park, J.-J. Kim, S.-G. Lee, Y.-J. Yoon, Synlett, 2009, 2809-2814.

Facile Synthesis of Symmetric and Unsymmetric 1,3,4-Oxadiazoles Using 2-Acyl(or aroyl)pyridazin-3-ones

Y.-D. Park, J.-J. Kim, H.-A. Chung, D.-H. Kweon, S.-D. Cho, S.-G. Lee, Y.-J. Yoon, Synthesis, 2003, 560-564.

Key Words

2-acylpyridazin-3-one, chemoselective N-acylation, pyridazinone, acetamides

ID: J66-Y2002-1500