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Iodine-Catalyzed, Efficient and Mild Procedure for Highly Chemoselective Acetalization of Carbonyl Compounds under Neutral Aprotic Conditions

Babak Karimi*, Behzad Golshani

*Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), P.O.Box 45195-159, Gava Zang, Zanjan, Iran, Email:

B. Karimi, B. Golshani, Synthesis, 2002, 784-788.

DOI: 10.1055/s-2002-25775


Various types of carbonyl compounds are efficiently converted to their 1,3-dioxanes by the use of 1,3-bis(trimethylsiloxy)propane (BTSP) and a catalytic amount of iodine under essentially neutral aprotic condition.

see article for more examples

Efficient and Chemoselective Conversion of Carbonyl Compounds to 1,3-Dioxanes Catalyzed with N-Bromosuccinimide under Almost Neutral Reaction Conditions

B. Karimi, G. R. Ebrahimian, H. Seradj, Org. Lett., 1999, 1, 1737-1739.

Key Words

carbonyl compounds, chemoselectivity, protection, 1,3-bis(trimethylsiloxy)propane, iodine, 1,3-dioxanes

ID: J66-Y2002-1510