Water Enables Direct Use of Allyl Alcohol for Tsuji-Trost Reaction without Activators
Hidenori Kinoshita, Hiroshi Shinokubo and Koichiro Oshima*
*Department of Material Chemistry, Graduate School of Engineering, Kyoto
University, Kyoto 615-8510, Japan, Email: oshima
orgrxn.mbox.media.kyoto-u.ac.jp
H. Kinoshita, H. Shinokubo, K. Oshima, Org. Lett., 2004, 6, 4085-4088.
DOI: 10.1021/ol048207a
Abstract
An aqueous biphasic reaction system enables the direct use of allyl alcohol in the Tsuji-Trost reaction without the help of any activating reagents. The neutral to basic reaction conditions allow the use of amines as nucleophiles.
see article for more reactions
Key Words
Trost Allylation, Allylation, Allylamines, Active Methylenes
ID: J54-Y2004-1340
