Synthesis of Substituted Oxindoles from α-Chloroacetanilides via Palladium-Catalyzed C-H Functionalization
Edward J. Hennessy and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: sbuchwalmit.edu
E. J. Hennessy, S. L. Buchwald, J. Am. Chem. Soc., 2003, 125, 12084-12085.
DOI: 10.1021/ja037546g (free Supporting Information)
A highly regioselective palladium-catalyzed cyclization converts α-chloroacetanilides to oxindoles in good to excellent yields with high functional group compatibility using 2-(di-tert-butylphosphino)biphenyl as ligand and triethylamine as a stoichiometric base.
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