Reduction of Ethanethiol Esters to Aldehydes
Hidetoshi Tokuyama, Satoshi Yokoshima, Shao-Cheng Lin, Leping Li, Tohru Fukuyama*
*Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1
Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email: fukuyama
mol.f.u-tokyo.ac.jp
H. Tokuyama, S. Yokoshima, S.-C. Lin, L. Li, T. Fukuyama, Synthesis, 2002, 1121-1123.
DOI: 10.1055/s-2002-31969
Abstract
Reduction of ethanethiol esters of α-amino acids to α-amino aldehydes by triethylsilane and catalytic palladium-on-carbon is described. α-Amino aldehydes with Boc, Cbz, or Fmoc protection could be obtained without racemization in high yield.
see article for more examples
Facile Palladium-Mediated Conversion of Ethanethiol Esters to Aldehydes and Ketones
H. Tokuyama, S. Yokoshima, T. Yamashita, S.-C. Lin, L. Li, T. Fukuyama, J. Braz. Chem. Soc., 1998, 9, 381-387.
Key Words
aldehydes, thioesters, amino aldehydes, Fukuyama reduction, triethylsilane
ID: J66-Y2002-1570
