Progressive Direct Iodination of Sterically Hindered Alkyl Substituted Benzenes
Stojan Stavber*, Petra Kralj, Marko Zupan
*Laboratory for Organic and Bioorganic Chemistry, ‘Joef Stefan' Institute and Department of Chemistry, University of Ljubljana, Jamova 39, 1000 Ljubljana, Slovenia, Email: stojan.stavberijs.si
S. Stavber, P. Kralj, M. Zupan, Synthesis, 2002, 1513-1518.
Benzene derivatives bearing at least one bulky alkyl group (i-Pr or t-Bu) were selectively and effectively iodinated using elemental iodine activated by Selectfluor. Up to three iodine atoms were progressively introduced at the most electron-rich and sterically less hindered position on the benzene ring.
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