Catalytic Asymmetric Rearrangement of Allylic Trichloroacetimidates. A Practical Method for Preparing Allylic Amines and Congeners of High Enantiomeric Purity
Carolyn E. Anderson and Larry E. Overman*
*Department of Chemistry, 516 Rowland Hall, University of California,
Irvine, California 92697-2025, Email: leoverma
uci.edu
C. E. Anderson, L. E. Overman, J. Am. Chem. Soc., 2003, 125, 12412-12413.
DOI: 10.1021/ja037086r
Abstract
COP-Cl catalyzes the rearrangement of (E)-allylic trichloroacetimidates to provide transposed allylic trichloroacetamides of high enantiopurity. This practical method for transforming prochiral allylic alcohols to enantioenriched allylic amines offers high functional group compatibility.
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Key Words
Allylamines, Overman Rearrangement
ID: J48-Y2003-1630
