Palladium-Catalyzed Negishi Cross-Coupling Reactions of Unactivated Alkyl Iodides, Bromides, Chlorides, and Tosylates

Jianrong Zhou and Gregory C. Fu*

*Contribution from the Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: gcfmit.edu

J. Zhou, G. C. Fu, J. Am. Chem. Soc., 2003, 125, 12527-12530.

DOI: 10.1021/ja0363258

---

Abstract

The use of 2% Pd₂(dba)₃/8% PCyp₃/NMI in THF/NMP at 80°C achieves the cross-coupling of a range of β-hydrogen-containing primary alkyl iodides, bromides, chlorides, and tosylates with an array of alkyl-, alkenyl-, and arylzinc halides. This method tolerates various functional groups.

see article for more examples

see article for more reactions

---

---

Key Words

Negishi Coupling, Alkanes, Alkenes

---

ID: J48-Y2003-1640