Organic Chemistry Portal



A New Copper Acetate-Bis(oxazoline)-Catalyzed, Enantioselective Henry Reaction

David A. Evans,* Daniel Seidel, Magnus Rueping, Hon Wai Lam, Jared T. Shaw and C. Wade Downey

*Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, Email:

D. A. Evans, D. Seidel, M. Rueping, H. W. Lam, J. T. Shaw, C. W. Downey, J. Am. Chem. Soc., 2003, 125, 12692-12693.

DOI: 10.1021/ja0373871


A highly enantioselective, nitroaldol reaction of both aromatic and aliphatic aldehydes catalyzed by a chiral Cu(II) bis(oxazoline) complex afforded products in good yields and enantioselectivities. The sense of asymmetric induction is discussed.

see article for more examples

Key Words

Henry Reaction

ID: J48-Y2003-1660