Aerobic Ruthenium-Catalyzed Oxidative Cyanation of Tertiary Amines with Sodium Cyanide

Shun-Ichi Murahashi,* Naruyoshi Komiya, Hiroyuki Terai and Takahiro Nakae

*Department of Applied Chemistry, Okayama University of Science, Ridai-cho 1-1, Okayama 700-0005, Japan, Email: murahashihigh.ous.ac.jp

S.-I. Murahashi, N. Komiya, H. Terai, T. Nakae, J. Am. Chem. Soc., 2003, 125, 15312-15313.

DOI: 10.1021/ja0390303

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Abstract

RuCl₃-catalyzed oxidative cyanation of tertiary amines with sodium cyanide under molecular oxygen at 60°C gives the corresponding α-aminonitriles in excellent yields. This reaction is clean and should be an environmentally benign and useful process.

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Key Words

Aminonitriles, Ruthenium, Oxygen, Green Chemistry

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ID: J48-Y2003-1680