A Novel Procedure for the Synthesis of Epoxides: Application of Simmons-Smith Reagents toward Epoxidation
Varinder K. Aggarwal, Amjad Ali and Michael P. Coogan
*School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8
1TS, UK, Email: v.aggarwal
bristol.ac.uk
V. K. Aggarwal, A. Ali, M. P. Coogan, J. Org. Chem., 1997, 125, 8628-8629.
DOI: 10.1021/jo971773h
Abstract
A novel application of organozinc reagents toward the epoxidation of carbonyl compounds via the intermediacy of sulfur ylides has been developed.
see article for more examples
Reaction Pathway
Developments in the Simmons-Smith-Mediated Epoxidation Reaction
V. K. Aggarwal, M. P. Coogan, R. A. Stenson, Ra. V. H. Jones, R. Fieldhouse, J. Blacker, Eur. J. Org. Chem., 2002, 319-326.
DOI: 10.1002/1099-0690(20021)2002:2<319::AID-EJOC319>3.0.CO;2-R
Key Words
Sulfonium Ylides, Epoxides, Corey-Chaykovsky Reaction
ID: J48-Y2003-1680
