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Tetrabutylammonium Peroxydisulfate in Organic Synthesis; XIII. A Simple and Highly Efficient One-Pot Synthesis of Nitriles by Nickel-Catalyzed Oxidation of Primary Alcohols with Tetrabutylammonium Peroxydisulfate

Fen-Er Chen*, Yong-Ye Li, Mei Xu, Hui-Qing Jia

*Department of Chemistry, Fudan University, Shanghai 200433, P. R. China, Email:

F.-E. Chen, Y.-Y. Li, M. Xu, H.-Q. Jia, Synthesis, 2002, 1804-1806.

DOI: 10.1055/s-2002-33906


A facile nickel-catalyzed oxidation of primary alcohols with tetrabutylammonium peroxydisulfate in the presence of ammonium hydrogen carbonate under basic aqueous conditions provides access to various aliphatic, aromatic and heterocyclic nitriles in excellent yields with very high purity.

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Key Words

tetrabutylammonium peroxydisulfate, nitriles, copper, primary alcohols, oxidation

ID: J66-Y2002-1640