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A General Method for the Suzuki-Miyaura Cross-Coupling of Sterically Hindered Aryl Chlorides: Synthesis of Di- and Tri-ortho-substituted Biaryls in 2-Propanol at Room Temperature

Oscar Navarro, Roy A. Kelly, III and Steven P. Nolan*

*School of Chemistry, University of St Andrews, St Andrews KY16 9ST, U.K., Email: sn17st-andrews.ac.uk

O. Navarro, R. A. Kelly, III, Steven P. Nolan, J. Am. Chem. Soc., 2003, 125, 16194-16195.

DOI: 10.1021/ja038631r


Abstract

The catalytic formation of di- and trisubstituted ortho biaryl junctions has been achieved using a palladacylce pre-catalyst bearing a N-heterocyclic carbene ligand at room temperature in technical grade 2-propanol.

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Modified (NHC)Pd(allyl)Cl (NHC = N-Heterocyclic Carbene) Complexes for Room-Temperature Suzuki-Miyaura and Buchwald-Hartwig Reactions

N. Marion, O. Navarro, J. Mei, E. D. Stevens, N. M. Scott, S. P. Nolan, J. Am. Chem. Soc., 2006, 128, 4101-4111.


Key Words

Suzuki Coupling


ID: J48-Y2003-1700