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A Mild and Highly Efficient Oxidation of Sulfides to Sulfoxides with Periodic Acid Catalyzed by FeCl3

Sung Soo Kim*, Kasi Nehru, Sang Soo Kim, Dong Won Kim, Hyun Chul Jung

*Department of Chemistry and Center for Chemical Dynamics, Inha University, Incheon 402-751, South Korea, Email:

S. S. Kim, K. Nehru, S. S. Kim, D. W. Kim, H. C. Jung, Synthesis, 2002, 2484-2486.

DOI: 10.1055/s-2002-35623


An excellent method for the selective oxidation of sulfides to sulfoxides with periodic acid (H5IO6) catalyzed by FeCl3 in MeCN has been devised. The reported procedure is fast, simple and the yields are excellent in most cases with reaction time of less than 2 minutes.

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proposed mechanism

Key Words

sulfides, sulfoxides, periodic acid, iron chloride, hypervalent

ID: J66-Y2002-1680