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Improved Conditions for Facile Overman Rearrangement

Toshio Nishikawa, Masanori Asai, Norio Ohyabu and Minoru Isobe*

*Laboratory of Organic Chemistry, Bioagricultural Sciences, Nagoya University, Furocho, Chikusa, Nagoya 464-8601, Japan, Email:

T. Nishikawa, M. Asai, N. Ohyabu, M. Isobe, J. Org. Chem., 1998, 63, 188-192.

DOI: 10.1021/jo9713924


The range of substrates that undergo the thermal Overman rearrangement effectively has been expanded by using K2CO3 as base in xylene at reflux. This modified Overman rearrangement is even more useful for syntheses of complex nitrogen-containing natural products.

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Key Words

Overman Rearrangement

ID: J42-1998-420