New N- and O-arylations with phenylboronic acids and cupric acetate
Dominic M. T. Chan*, Kevin L. Monaco, Ru-Ping Wang and Michael P. Winters
*DuPont Crop Protection, Stine-Haskell Research Center, P.O. Box 30, Newark,
DE 19714-0030, USA, Email: dominic.m.chan
usa.dupont.com
D. M. T. Chan, K. L. Monaco, R.-P. Wang, M. P. Winteres, Tetrahedron Lett., 1998, 39, 2933-2936.
DOI: 10.1016/S0040-4039(98)00503-6
Abstract
The arylation of N-H and O-H containing compounds at room temperature with phenylboronic acids is promoted in the presence of cupric acetate and a tertiary amine. Substrates include phenols, amines, anilines, amides, imides, ureas, carbamates, and sulfonamides.
see article for more examples
New aryl/heteroaryl C-N bond cross-coupling reactions via arylboronic acid/cupric acetate arylation
P. Y. S. Lam, C. G. Clark, S. Saubern, J. Adams, M. P. Winters, D. M. T. Chan, A. Combs, Tetrahedron Lett., 1998, 39, 2941-2944.
Key Words
Chan-Lam Coupling, Arylamines, Diarylethers, Amides, Carbamates, Sulfonamides, Urea Derivatives
ID: J72-Y1998-430
