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New N- and O-arylations with phenylboronic acids and cupric acetate

Dominic M. T. Chan*, Kevin L. Monaco, Ru-Ping Wang and Michael P. Winters

*DuPont Crop Protection, Stine-Haskell Research Center, P.O. Box 30, Newark, DE 19714-0030, USA, Email:

D. M. T. Chan, K. L. Monaco, R.-P. Wang, M. P. Winteres, Tetrahedron Lett., 1998, 39, 2933-2936.

DOI: 10.1016/S0040-4039(98)00503-6


The arylation of N-H and O-H containing compounds at room temperature with phenylboronic acids is promoted in the presence of cupric acetate and a tertiary amine. Substrates include phenols, amines, anilines, amides, imides, ureas, carbamates, and sulfonamides.

see article for more examples

New aryl/heteroaryl C-N bond cross-coupling reactions via arylboronic acid/cupric acetate arylation

P. Y. S. Lam, C. G. Clark, S. Saubern, J. Adams, M. P. Winters, D. M. T. Chan, A. Combs, Tetrahedron Lett., 1998, 39, 2941-2944.

Key Words

Chan-Lam Coupling, Arylamines, Diarylethers, Amides, Carbamates, Sulfonamides, Urea Derivatives

ID: J72-Y1998-430