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Facile Synthesis of Symmetric and Unsymmetric 1,3,4-Oxadiazoles Using 2-Acyl(or aroyl)pyridazin-3-ones

Yong-Dae Park, Jeum-Jong Kim, Hyun-A Chung, Deok-Heon Kweon, Su-Dong Cho, Sang-Gyeong Lee, Yong-Jin Yoon*

*Department of Chemistry and Research Institute of Natural Sciences, Gyeongsang National University, Chinju 660-701, Korea, Email:

Y.-D. Park, J.-J. Kim, H.-A. Chung, D.-H. Kweon, S.-D. Cho, S.-G. Lee, Y.-J. Yoon, Synthesis, 2003, 560-564.

DOI: 10.1055/s-2003-37647

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Symmetric and unsymmetric 1,3,4-oxadiazoles were synthesized in situ from hydrazine hydrate and the corresponding 2-acyl-4,5-dichloropyridazin-3-ones as acylating agents in polyphosphoric acid (PPA) or BF3ˇOEt2 in excellent yields.

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2-Acylpyridazin-3-ones: Novel Mild and Chemoselective Acylating Agents for Amines

Y.-J. Kang, H.-A Chung, J.-J. Kim, Y.-J. Yoon, Synthesis, 2002, 733-738.

Key Words

2-acyl-4,5-dichloropyridazin-3-ones, 1,3,4-oxadiazoles, cyclodehydration

ID: J66-Y2003-1800