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Synthesis of N-Benzhydrylamides from Nitriles by Ritter Reactions in Formic Acid

Glen C. Gullickson, David E. Lewis*

*Department of Chemistry, University of Wisconsin - Eau Claire, Eau Claire WI 54702-4004, USA, Email:

G. C. Gullickson, D. E. Lewis, Synthesis, 2003, 681-684.

DOI: 10.1055/s-2003-38069


Benzhydrol reacts with nitriles in refluxing formic acid to produce amides arising from the Ritter reaction. The mild conditions permit the preparation of acrylamides and methacrylamides without polymerization of the nitrile.

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Key Words

Ritter reaction, alcohols, carboxylic acids, nitriles, amides

ID: J66-Y2003-1810