Synthesis of N-Benzhydrylamides from Nitriles by Ritter Reactions in Formic Acid
Glen C. Gullickson, David E. Lewis*
*Department of Chemistry, University of Wisconsin - Eau Claire, Eau Claire
WI 54702-4004, USA,
Email: lewisd
uwec.edu
G. C. Gullickson, D. E. Lewis, Synthesis, 2003, 681-684.
DOI: 10.1055/s-2003-38069
Abstract
Benzhydrol reacts with nitriles in refluxing formic acid to produce amides arising from the Ritter reaction. The mild conditions permit the preparation of acrylamides and methacrylamides without polymerization of the nitrile.
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Key Words
Ritter reaction, alcohols, carboxylic acids, nitriles, amides
ID: J66-Y2003-1810
