Catalytic Generation of Activated Carboxylates: Direct, Stereoselective Synthesis of β-Hydroxyesters from Epoxyaldehydes
Kenneth Yu-Kin Chow and Jeffrey W. Bode*
*Laboratorium für Organische Chemie, Department of Chemistry
and Applied Biosciences, ETH-Zürich, Wolfgang Pauli Strasse 10, 8093 Zürich,
Switzerland, Email: bode
org.chem.ethz.ch
K. Y.-K. Chow, J. W. Bode, J. Am. Chem. Soc., 2004, 126, 8126-8127.
DOI: 10.1021/ja047407e
Abstract
The catalytic generation of activated carboxylates from epoxyaldehydes enables a direct, anti-selective, convenient and mild synthesis of β-hydroxyesters.
see article for more examples
Catalytic Generation of Activated Carboxylates from Enals: A Product-Determining Role for the Base
S. S. Sohn, J. W. Bode, Org. Lett., 2005, 7, 3873-3876.
Key Words
Redox Esterification, Epoxides, β-Hydroxy esters, Organocatalysis
ID: J48-Y2004-1550
