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New Protocol for Efficient N-Chlorinations of Amides and Carbamates

Oleg V. Larionov, Sergei I. Kozhushkov, Armin de Meijere*

*Institut für Organische Chemie der Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany, Email:

O. V. Larionov, S. I. Kozhushkov, A. de Meijere, Synthesis, 2003, 1916-1919.

DOI: 10.1055/s-2003-41037


N-Chlorination of various amides, carbamates and lactams with inexpensive and stable calcium hypochlorite on moist alumina proceeds smoothly and efficiently. Excellent results were also observed for the N-chlorination of protected amino acid esters with a cyclopropane moiety.

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Key Words

amides, amino acids, N-chlorination, calcium hypochlorite, alumina

ID: J66-Y2003-1950