Phase-transfer-catalyzed asymmetric Darzens reaction
Shigeru Arai*, Yoshiki Shirai, Toshimasa Ishida and Takayuki Shioiri
*Graduate School of Pharmaceutical Sciences, Chiba University, 1-33
Yayoi-Cho, Inage-ku, Chiba 263-8522, Japan,
Email: arai
p.chiba-u.ac.jp
S. Arai, Y. Shirai, T. Ishida, T. Shioiri, Tetrahedron, 1999, 55, 6375-6386.
DOI: 10.1016/S0040-4020(99)00213-6
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Abstract
Catalytic asymmetric Darzens reactions of α-chloro acyclic and cyclic ketones promoted by a chiral phase-transfer catalyst derived from cinchonine gave the desired α,β-epoxy ketones with moderate to high enantiomeric excesses under mild reaction conditions.
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Key Words
Epoxides, Darzens Condensation, Asymmetric Catalyst, Phase Transfer, Organocatalysis
ID: J72-Y1999-450
