Platinum-Catalyzed Intramolecular Hydroalkoxylation of γ- and δ-Hydroxy Olefins to Form Cyclic Ethers

Hua Qian, Xiaoqing Han and Ross A. Widenhoefer*

*P. M. Gross Chemical Laboratory, Duke University, Durham, North Carolina 27708-0346, Email: rwidenhochem.duke.edu

H. Qian, X. Han, R. A. Widenhoefer, J. Am. Chem. Soc., 2004, 126, 9536-9537.

DOI: 10.1021/ja0477773

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Abstract

The platinum-catalyzed hydroalkoxylation of γ- and δ-hydroxy olefins tolerated various substitution patterns and a number of functional groups including pivaloate and acetate esters, amides, silyl and benzyl ethers, and pendant hydroxyl and olefinic groups.

see article for more examples

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Highly Active Au(I) Catalyst for the Intramolecular exo-Hydrofunctionalization of Allenes with Carbon, Nitrogen, and Oxygen Nucleophiles

Z. Zhang, C. Liu, R. E. Kinder, X. Han, H. Qian, R. A. Widenhoefer, J. Am. Chem. Soc., 2006, 128, 9066-9073.

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Key Words

cyclic ethers

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ID: J48-Y2004-1630