Selective Access to Secondary Amines by a Highly Controlled Reductive Mono-N-Alkylation of Primary Amines
Hephzibah J. Kumpaty, Sukanta Bhattacharyya*, Erik W. Rehr, Amelia M. Gonzalez
*Argonaut Technologies, 1101 Chess Drive, Foster City, CA 94404, USA, Email: sbhattacharyyaargotech.com
H. J. Kumpaty, S. Bhattacharyya, E. W. Rehr, A. M. Gonzalez, Synthesis, 2003, 2206-2210.
A selective and direct access to secondary amines by reductive mono-N-alkylation of primary amines with carbonyl compounds in the presence of Ti(i-PrO)4 and NaBH4 gave exclusively secondary amines.
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B. Miriyala, S. Bhattacharyya, J. S. Williamson, Tetrahedron, 2004, 60, 1463-1471.