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Palladium-Catalyzed Oxygenation of Unactivated sp3 C-H Bonds

Lopa V. Desai, Kami L. Hull and Melanie S. Sanford*

*Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, Email:

L. V. Desai, K. L . Hull, M. S. Sanford, J. Am. Chem. Soc., 2004, 126, 9542-9543.

DOI: 10.1021/ja046831c


A new palladium-catalyzed method allows the oxygenation of unactivated sp3 C-H bonds of a wide variety of alkane substrates containing readily available oxime and/or pyridine directing groups with extremely high levels of chemo-, regio-, and in some cases diastereoselectivity.

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Key Words

β-hydroxy carbonyl compounds, esters, iodosobenzene diacetate

ID: J48-Y2004-1650