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Synthesis of New Arylhydroxymethylphosphinic Acids and Derivatives

H.-J. Cristau*, A. Hervé, F. Loiseau, D. Virieux*

*Laboratoire de Chimie Organique, UMR 5076, Ecole Nationale Supérieure de Chimie de Montpellier, 8, Rue de l'Ecole Normale, 34296 Montpellier Cedex 5, France, Email:,

H.-J. Cristau, A. Hervé, F. Loiseau, D. Virieux, Synthesis, 2003, 2216-2220.

DOI: 10.1055/s-2003-41045

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Arylhydroxymethylphosphinic acid derivatives were prepared by a palladium(0) catalysed arylation of ethyl benzyl­oxymethylphosphinate with aryl halides followed by subsequent hydrogenolysis of the benzyl protecting group and hydrolysis of the ester function.

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Key Words

phosphorus, phosphinates, palladium, arylations, protecting groups, benzyl ethers

ID: J66-Y2003-2020