Organic Chemistry Portal



Synthesis of Vinyl Sulfonamides Using the Horner Reaction

Deborah C. Reuter*, Joel E. McIntosh, Ashley C. Guinn, Ann Marie Madera

*Department of Medicinal Chemistry, Roche Palo Alto, 3431 Hillview Ave. R6E-3, Palo Alto, CA 94304, USA, Email:

D. C. Reuter, J. E. McIntosh, A. C. Guinn, A. M. Madera, Synthesis, 2003, 2321-2324.

DOI: 10.1055/s-2003-41059


A series of vinyl sulfonamides was synthesized using the Horner reaction of aldehydes and diphenylphosphorylmethanesulfonamide. The sulfonamide reagent was easily prepared and can be stored indefinitely.

see article for more examples

Key Words

Wittig-Horner reaction, sulfonamides, E-alkenes, Horner reaction, aldehydes, ylides

ID: J66-Y2003-2040