Further functional group oxidations using sodium perborate

Alexander McKillop* and Duncan Kemp

*School of Chemical Sciences, University of East Anglia, Norwich, NR4 7TJ, England

A. McKillop, D. Kemp, Tetrahedron, 1989, 45, 3299-3306.

DOI: 10.1016/S0040-4020(01)81008-5

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Abstract

Sodium perborate in acetic acid is an effective reagent for the oxidation of aromatic aldehydes to carboxylic acids, iodoarenes to (diacetoxyiodo)arenes, azines to N-oxides, and various sulphur heterocycles to S,S-dioxides. Nitriles undergo smooth oxidative hydration to amides when aqueous methanol is employed as solvent.

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Key Words

Carboxylic Acids, Hypervalent Iodine(III) Compounds, N-Oxides, Amides, Sodium Perborate

ID: J72-Y1989-060