CuBr-Catalyzed Efficient Alkynylation of sp3 C-H Bonds Adjacent to a Nitrogen Atom
Zhiping Li and Chao-Jun Li*
*Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada, Email: cj.limcgill.ca
Z. Li, C.-J. Li, J. Am. Chem. Soc., 2004, 126, 11810-11811.
DOI: 10.1021/ja0460763 (free Supporting Information)
A simple and effective copper-catalyzed oxidative cross-coupling of dimethylanilines with alkynes in the presence of tert-BuOOH allows the construction of propargylamines via a combination of sp3 C-H bond and sp C-H bond activations followed by C-C bond formation.
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