A Selective and Mild Oxidation of Primary Amines to Nitriles with Trichloroisocyanuric Acid
Fen-Er Chen*, Yun-Yan Kuang, Hui-Fang Dai, Liang Lu, Ming Huo
*Department of Chemistry, Fudan University, Shanghai, 200433, P. R. China, Email: rfchenfudan.edu.cn
F.-E. Chen, Y.-Y. Kuang, H.-F. Dai, L. Lu, M. Huo, Synthesis, 2003, 2629-2631.
An efficient and highly selective method for the oxidative conversion of primary amines to the corresponding nitriles using trichloroisocyanuric acid in the presence of catalytic TEMPO provides a new entry to the synthesis of various aliphatic, aromatic and heterocyclic nitriles in excellent yield.
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