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A Selective and Mild Oxidation of Primary Amines to Nitriles with Trichloroisocyanuric Acid

Fen-Er Chen*, Yun-Yan Kuang, Hui-Fang Dai, Liang Lu, Ming Huo

*Department of Chemistry, Fudan University, Shanghai, 200433, P. R. China, Email:

F.-E. Chen, Y.-Y. Kuang, H.-F. Dai, L. Lu, M. Huo, Synthesis, 2003, 2629-2631.

DOI: 10.1055/s-2003-42431


An efficient and highly selective method for the oxidative conversion of primary amines to the corresponding nitriles using trichloroisocyanuric acid in the presence of catalytic TEMPO provides a new entry to the synthesis of various aliphatic, aromatic and heterocyclic nitriles in excellent yield.

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Key Words

TEMPO, Trichloroisocyanuric Acid, Organocatalysis, Nitriles, Oxidation, Catalysis

ID: J66-Y2003-2100