An Extremely Active Catalyst for the Negishi Cross-Coupling Reaction
Jacqueline E. Milne and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: sbuchwalmit.edu
J. E. Milne, S. L. Buchwald, J. Am. Chem. Soc., 2004, 126, 13028-13032.
A new catalyst system for the Pd-catalyzed cross-coupling of organozinc reagents with aryl halides permits efficient preparation of hindered biaryls, functions effectively at low levels of catalyst, and tolerates a wide range of functional groups and heterocyclic substrates.
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Negishi Coupling, Biaryls, Heterobiaryls