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An Extremely Active Catalyst for the Negishi Cross-Coupling Reaction

Jacqueline E. Milne and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

J. E. Milne, S. L. Buchwald, J. Am. Chem. Soc., 2004, 126, 13028-13032.

DOI: 10.1021/ja0474493


A new catalyst system for the Pd-catalyzed cross-coupling of organozinc reagents with aryl halides permits efficient preparation of hindered biaryls, functions effectively at low levels of catalyst, and tolerates a wide range of functional groups and heterocyclic substrates.

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Key Words

Negishi Coupling, Biaryls, Heterobiaryls

ID: J48-Y2004-1740