Efficient Conversions of Carboxylic Acids into O-Alkyl, N-Alkyl and O,N-Dialkylhydroxamic Acids
Alan R. Katritzky*, Nataliya Kirichenko, Boris V. Rogovoy
*Center for Heterocyclic Compounds, Department of Chemistry, University of
Florida, Gainesville, FL 32611-7200, USA, Email: Katritzky
chem.ufl.edu
A. R. Katritzky, N. Kirichenko, B. V. Rogovoy, Synthesis, 2003, 2777-2780.
DOI: 10.1055/s-2003-42488
Abstract
Carboxylic acids were conveniently converted into unsubstituted, N-alkyl-, O-alkyl-, and O,N-dialkylhydroxamic acids via acylbenzotriazole intermediates. The ready availability of the reagents, mild conditions, and easy handling of the intermediates are advantageous.
see article for more examples
Efficient Conversion of Carboxylic Acids into N-Acylbenzotriazoles
A. R. Katritzky, N. Kirichenko, B. V. Rogovoy, Synthesis, 2003, 2777-2780.
Key Words
Hydroxamic acid derivatives, Weinreb amides, carboxylic acids, regioselectivity, nucleophilic
ID: J66-Y2003-2130
