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Efficient Conversion of Carboxylic Acids into N-Acylbenzotriazoles

Alan R. Katritzky*, Yuming Zhang, Sandeep K. Singh

*Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA, Email:

A. R. Katritzky, N. Kirichenko, B. V. Rogovoy, Synthesis, 2003, 2777-2780.

DOI: 10.1055/s-2003-42462


An improved one-pot procedure for the preparation of N-acylbenzotriazoles involves mild reaction conditions and allows the preparation of several derivatives not accessible by the previously reported methods.

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N-Acylbenzotriazoles:  Neutral Acylating Reagents for the Preparation of Primary, Secondary, and Tertiary Amides

A. R. Katritzky, H.-Y. He, K. Suzuki, J. Org. Chem., 2000, 65, 8210-8213.

Efficient Microwave Access to Polysubstituted Amidines from Imidoylbenzotriazoles

A. R. Katritzky, C. Cai, S. K. Singh, J. Org. Chem., 2006, 71, 3375-3380.

Key Words

N-acylbenzotriazole, carboxylic acid, benzotriazole, thionyl chloride, acylation reagent

ID: J66-Y2003-2140