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Straightforward Novel One-Pot Enaminone and Pyrimidine Syntheses by Coupling-Addition-Cyclocondensation Sequences

Alexei S. Karpov, Thomas J. J. Müller*

*Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität, Universitätsstr. 1, 40225 Düsseldorf, Germany, Email:

A. S. Karpov, T. J. J. Müller, Synthesis, 2003, 2815-2826.

DOI: 10.1055/s-2003-42480

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The coupling of acid chlorides with terminal alkynes using one equivalent of triethylamine under Sonogashira conditions followed by subsequent addition of amines or amidinium salts to the intermediate alkynones allows a straightforward access to enaminones and pyrimidines under mild conditions and in excellent yields.

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Key Words

catalysis, sonogashira coupling, enaminones, pyrimidines

ID: J66-Y2003-2150