Straightforward Novel One-Pot Enaminone and Pyrimidine Syntheses by Coupling-Addition-Cyclocondensation Sequences
Alexei S. Karpov, Thomas J. J. Müller*
*Institut für Organische Chemie und Makromolekulare Chemie,
Heinrich-Heine-Universität, Universitätsstr. 1, 40225 Düsseldorf, Germany, Email:
ThomasJJ.Mueller
uni-duesseldorf.de
A. S. Karpov, T. J. J. Müller, Synthesis, 2003, 2815-2826.
DOI: 10.1055/s-2003-42480
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Abstract
The coupling of acid chlorides with terminal alkynes using one equivalent of triethylamine under Sonogashira conditions followed by subsequent addition of amines or amidinium salts to the intermediate alkynones allows a straightforward access to enaminones and pyrimidines under mild conditions and in excellent yields.
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Key Words
catalysis, sonogashira coupling, enaminones, pyrimidines
ID: J66-Y2003-2150
