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Straightforward Novel One-Pot Enaminone and Pyrimidine Syntheses by Coupling-Addition-Cyclocondensation Sequences

Alexei S. Karpov, Thomas J. J. Müller*

*Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität, Universitätsstr. 1, 40225 Düsseldorf, Germany, Email: ThomasJJ.Muelleruni-duesseldorf.de

A. S. Karpov, T. J. J. Müller, Synthesis, 2003, 2815-2826.

DOI: 10.1055/s-2003-42480


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Abstract

The coupling of acid chlorides with terminal alkynes using one equivalent of triethylamine under Sonogashira conditions followed by subsequent addition of amines or amidinium salts to the intermediate alkynones allows a straightforward access to enaminones and pyrimidines under mild conditions and in excellent yields.


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Key Words

catalysis, sonogashira coupling, enaminones, pyrimidines


ID: J66-Y2003-2150