Zinc Mediated Friedel-Crafts Acylation in Solvent-Free Conditions under Microwave Irradiation
Satya Paul, Puja Nanda, Rajive Gupta*, André Loupy
*Department of Chemistry, University of Jammu, Jammu-180 006, India, Email: rajguptasancharnet.in
S. Paul, P. Nanda, R. Gupta, A. Loupy, Synthesis, 2003, 2877-2881.
Zn powder catalyzes the Friedel-Crafts acylation of aromatic compounds with acyl halides efficiently under microwave irradiation in solvent-free conditions. Activated substrates undergo acylation predominantly at the para-position. The Zn powder can be re-used up to six times after simple washing with diethyl ether and dilute HCl.
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S. Paul, M. Gupta, Synthesis, 2004, 1789-1792.