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Zinc Mediated Friedel-Crafts Acylation in Solvent-Free Conditions under Microwave Irradiation

Satya Paul, Puja Nanda, Rajive Gupta*, André Loupy

*Department of Chemistry, University of Jammu, Jammu-180 006, India, Email:

S. Paul, P. Nanda, R. Gupta, A. Loupy, Synthesis, 2003, 2877-2881.

DOI: 10.1055/s-2003-42485


Zn powder catalyzes the Friedel-Crafts acylation of aromatic compounds with acyl halides efficiently under microwave irradiation in solvent-free conditions. Activated substrates undergo acylation predominantly at the para-position. The Zn powder can be re-used up to six times after simple washing with diethyl ether and dilute HCl.

see article for more examples

Selective Fries Rearrangement Catalyzed by Zinc Powder

S. Paul, M. Gupta, Synthesis, 2004, 1789-1792.

Key Words

Friedel-Crafts Acylation, zinc powder,aromatic compounds, solvent-free conditions, microwave synthesis

ID: J66-Y2003-2160