Cooperative Catalysis of a Cationic Ruthenium Complex, Amine Base, and Na Salt: Catalytic Activation of Acetonitrile as a Nucleophile
Naoya Kumagai, Shigeki Matsunaga and Masakatsu Shibasaki*
*Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email: mshibasamol.f.u-tokyo.ac.jp
N. Kumagai, S. Matsunaga, M. Shibasaki, J. Am. Chem. Soc., 2004, 126, 13632-13633.
Cooperative catalysis of a cationic Ru complex, DBU, and NaPF6 enabled activation of acetonitrile as a nucleophile under mild basic conditions. The nucleophilic 1,2-addition of in situ-generated, Ru-bound, metalated nitrile to aldehydes and imines proceeded smoothly.
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