Reagents for Efficient Conversion of Amines to Protected Guanidines
Tomasz Gers, Danuta Kunce, Paweł Markowski, Jan Izdebski*
*Laboratory of Peptides, Department of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland, Email: izdebskichem.uw.edu.pl
T. Gers, D. Kunce, P. Markowski, J. Izdebski, Synthesis, 2004, 37-42.
DOI: 10.1055/s-2003-44374
Abstract
Two new guanidinylation reagents, N,N′-bis(ortho-chloro-Cbz)-S-methylisothiourea and N,N′-bis(ortho-bromo-Cbz)-S-methylisothiourea, proved to be superior to already known reagents. The guanidinylations of amines with all reagents were accelerated by addition of DMAP.
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Key Words
guanidines, guanidinylation, guanylation, isothioureas, protecting groups
ID: J66-Y2004-1820