Organic Chemistry Portal

Abstracts

Search:

Reagents for Efficient Conversion of Amines to Protected Guanidines

Tomasz Gers, Danuta Kunce, Paweł Markowski, Jan Izdebski*

*Laboratory of Peptides, Department of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland, Email: izdebskichem.uw.edu.pl

T. Gers, D. Kunce, P. Markowski, J. Izdebski, Synthesis, 2004, 37-42.

DOI: 10.1055/s-2003-44374


Abstract

Two new guanidinylation reagents, N,N′-bis(ortho-chloro-Cbz)-S-methylisothiourea and N,N′-bis(ortho-bromo-Cbz)-S-methylisothiourea, proved to be superior to already known reagents. The guanidinylations of amines with all reagents were accelerated by addition of DMAP.


see article for more examples



Key Words

guanidines, guanidinylation, guanylation, isothioureas, protecting groups


ID: J66-Y2004-1820