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Organic Reactions in Ionic liquids: N-Alkylation of Phthalimide and Several Nitrogen Heterocycles

Zhang-Gao Le, Zhen-Chu Chen*, Yi Hu, Qin-Guo Zheng

*Department of Chemistry, Zhejiang University (xi xi campus), Hangzhou, 310028, P. R. China, Email:

Z.-G. Le, Z.-C. Chen, Y. Hu, Q.-G. Zheng, Synthesis, 2004, 208-212.

DOI: 10.1055/s-2003-44383

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A convenient, efficient, and selective N-Alkylation of N-acidic heterocyclic compounds with alkyl halides is accomplished in ionic liquids in the presence of potassium hydroxide as a base. In this manner, phthalimide, indole, benzimidazole, and succinimide can be successfully alkylated.

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Organic Reactions in Ionic Liquids: A Simple and Highly Regioselective N-Substitution of Pyrrole

Z.-G. Lea, Z.-C. Chen, Y. Hu, Q.-G. Zheng Synthesis, 2004, 1951-1954.

Key Words

ionic liquids, N-alkylation, imides, Gabriel synthesis, Phthalimides

ID: J66-Y2004-1920