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Mild and Efficient Silylcyanation of Ketones Catalyzed by N-Methylmorpholine N-Oxide

Sung Soo Kim*, Dong Won Kim, Gurusamy Rajagopal

*Department of Chemistry and Center for Chemical Dynamics, Inha University, Incheon 402-751, South Korea, Email:

S. S. Kim, D. W. Kim, G. Rajagopal, Synthesis, 2004, 213-216.

DOI: 10.1055/s-2003-44380


An efficient method for achiral addition of TMSCN to ketones employs N-methylmorpholine N-oxide as catalyst. A variety of aromatic, aliphatic, cyclic and heterocyclic ketones are converted into their corresponding trimethylsilyl ethers in excellent yields.

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Niobium Fluoride (NbF5): A Highly Efficient Catalyst for Solvent-Free Cyanosilylation of Aldehydes

S. S. Kim, G. Rajagopal, Synthesis, 2007, 215-218.

Key Words

silylcyanation, NMO, TMSCN, ketone, cyanohydrins

ID: J66-Y2004-1930