Mild and Efficient Silylcyanation of Ketones Catalyzed by N-Methylmorpholine N-Oxide
Sung Soo Kim*, Dong Won Kim, Gurusamy Rajagopal
*Department of Chemistry and Center for Chemical Dynamics, Inha University, Incheon 402-751, South Korea, Email: sungsooinha.ac.kr
S. S. Kim, D. W. Kim, G. Rajagopal, Synthesis, 2004, 213-216.
DOI: 10.1055/s-2003-44380
Abstract
An efficient method for achiral addition of TMSCN to ketones employs N-methylmorpholine N-oxide as catalyst. A variety of aromatic, aliphatic, cyclic and heterocyclic ketones are converted into their corresponding trimethylsilyl ethers in excellent yields.
see article for more examples
Niobium Fluoride (NbF5): A Highly Efficient Catalyst for Solvent-Free Cyanosilylation of Aldehydes
S. S. Kim, G. Rajagopal, Synthesis, 2007, 215-218.
Key Words
silylcyanation, NMO, TMSCN, ketone, cyanohydrins
ID: J66-Y2004-1930