Nickel-Catalyzed Cross-Coupling Reaction of Aryl Fluorides and Chlorides with Grignard Reagents under Nickel/Magnesium Bimetallic Cooperation
Naohiko Yoshikai, Hiroko Mashima and Eiichi Nakamura*
*Department of Chemistry, The University of Tokyo, and Nakamura Functional Carbon Cluster Project, ERATO, Japan Science and Technology Agency, Bunkyo-ku, Tokyo 113-0033, Japan, Email: nakamurachem.s.u-tokyo.ac.jp
N. Yoshikai, H. Mashima, E. Nakamura, J. Am. Chem. Soc., 2005, 127, 17978-17979.
DOI: 10.1021/ja056327n (free Supporting Information)
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Nickel-catalyzed cross-coupling of Grignard reagents with aryl fluorides or chlorides can be achieved efficiently in the presence of a new triarylphosphine ligand. The high reactivity and the unique chemoselectivity of the catalysis have been attributed to synergy of nickel and magnesium atoms preorganized on the ligand.
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N. Yoshikai, H. Matsuda, E. Nakamura, J. Am. Chem. Soc., 2009, 131, 9590-9599.