Er(OTf)₃ as a Mild Cleaving Agents for Acetals and Ketals

Renato Dalpozzo, Antonio De Nino, Loredana Maiuolo, Monica Nardi, Antonio Procopio*, Antonio Tagarelli

*Dipartimento Farmaco-Biologico, Università degli Studi della Magna Graecia, Complesso Ninì Barbieri, Roccelletta di Borgia (CZ), Italy, Email: procopiounicz.it

R. Dalpozzo, A. De Nino, L. Maiuolo, M. Nardi, A. Procopio, A. Tagarelli, Synthesis, 2004, 496-498.

DOI: 10.1055/s-2004-815941

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Abstract

Er(OTf)₃ is a very gentle Lewis acid catalyst in the chemoselective cleavage of alkyl and cyclic acetals and ketals at room temperature in wet nitromethane.

see article for more examples

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Mild and efficient method for the cleavage of benzylidene acetals by using erbium (III) triflate

A. Procopio, R. Dalpozzo, A. De Nino, L. Maiuolo, M. Nardi, G. Romeo, Org. Biomol. Chem., 2005, 3, 4129-4133.

Simple and Efficient Chemoselective Mild Deprotection of Acetals and Ketals Using Cerium(III) Triflate

R. Dalpozzo, A. De Nino, L. Maiuolo, A. Procopio, A. Tagarelli, G. Sindona, G. Bartoli, J. Org. Chem., 2002, 67, 9093-9095.

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Key Words

erbium(III) triflate, Lewis acid catalyst, cleavage (acetals, ketals), 1,3-dioxolanes, dimethyl acetals

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ID: J66-Y2004-1970