Gold(III)-Catalyzed Annulation of 2-Alkynylanilines: A Mild and Efficient Synthesis of Indoles and 3-Haloindoles
Antonio Arcadi, Gabriele Bianchi, Fabio Marinelli*
*Dipartimento di Chimica, Ingegneria Chimica e Materiali, Facoltà di Scienze,
via Vetoio, 67100 L'Aquila, Italy, Email: fmarinel
univaq.it
A. Arcadi, G. Bianchi, F. Marinelli, Synthesis, 2004, 610-618.
DOI: 10.1055/s-2004-815947
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Abstract
Gold(III)-catalyzed annulation of 2-alkynylanilines in EtOH or EtOH-water mixtures at room temperature gives indoles derivatives in good yields. One-flask protocol for the gold-catalyzed conversion of 2-alkynylanilines to 3-bromo and 3-iodoindoles is also reported.
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Key Words
2-alkynylanilines, indoles, 5-endo-dig cyclization, gold catalysis, halogenations
ID: J66-Y2004-2000
