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N-Bromosuccinimide as an Almost Neutral Catalyst for Efficient Synthesis of Dihydropyrimidinones Under Microwave Irradiation

Hassan Hazarkhani, Babak Karimi*

*Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), P.O.Box 45195-159, Gava Zang, Zanjan, Iran, Email:

H. Hazarkhani, B. Karimi, Synthesis, 2004, 1239-1242.

DOI: 10.1055/s-2004-822348


NBS has been used as a mild, efficient and almost neutral catalyst for the preparation of dihydropyrimidinones (DHPMs) and the corresponding thio-derivatives under microwave irradiation. A wide variety of DHPMs were synthesized in good to high yields.

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Key Words

Biginelli Reaction, N-bromosuccinimide, dihydropyrimidinones, microwave synthesis

ID: J66-Y2004-2070