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Iron(III) Chloride Catalysis of the Acetal-Ene Reaction

Arnaud Ladépêche, Eric Tam, Jean-Erick Ancel, Léon Ghosez*

*European Institute of Chemistry and Biology (IECB), Rue Robert Escarpit 2, 33607 Pessac Cedex, France, Email:

A. Ladépêche, E. Tam, J.-E. Ancel, L. Ghosez, Synthesis, 2004, 1375-1380.

DOI: 10.1055/s-2004-822399


Iron(III) chloride is a very efficient catalyst in the acetal-ene reaction involving 1,1-disubstituted alkenes.

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proposed mechanism

Key Words

ene reaction, acetals, ethers, catalysis, iron, Lewis acids

ID: J66-Y2004-2090