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Ferric chloride/tetraethyl orthosilicate as an efficient system for synthesis of dihydropyrimidinones by Biginelli reaction

Ivica Cepanec, Mladen Litvić, Anamarija Bartolinčić and Marija Lovrić

*BELUPO Pharmaceuticals, Research Department, Radnička c. 224, 10000 Zagreb, Croatia, Email:

I. Cepanec, M. Litvić, A. Bartolinčić, M. Lovrić, Tetrahedron, 2005, 61, 4275-4280.

DOI: 10.1016/j.tet.2005.02.059


An efficient method for the Biginelli reaction of aldehydes, acetoacetate esters and urea employing tetraethyl orthosilicate in the presence of ferric chloride allows the preparation of a wide variety of substituted dihydropyrimidinones in high yields and purity under mild reaction conditions.

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Key Words

Biginelli Reaction, Multicomponent Reactions

ID: J72-Y2005-2810