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Facile Yb(OTf)3 promoted one-pot synthesis of polyhydroquinoline derivatives through Hantzsch reaction

Li-Min Wang*, Jia Sheng, Liang Zhang, Jian-Wei Han, Zhao-Yu Fan, He Tian and Chang-Tao Qian

*Laboratory for Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Lu, Shanghai 200237, People's Republic of China, Email:

L.-M. Wang, J. Sheng, L. Zhang, J.-W. Han, Z.-Y. Fan, H. Tian, C.-T. Qian, Tetrahedron, 2005, 61, 1539-1543.

DOI: 10.1016/j.tet.2004.11.079


Yb(OTf)3 catalyzed an efficient, operationally simple and environmentally benign Hantzsch reaction via a four-component coupling reaction of aldehydes, dimedone, ethyl acetoacetate and ammonium acetate at ambient temperature to yield polyhydroquinoline derivatives in excellent yield.

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Key Words

Dihydropyridines, Dimedone, Polyhydroquinoline, Hantzsch Synthesis, Multicomponent Reactions

ID: J72-Y2005-2820