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Tributylphosphine as a superior catalyst for the α-C-addition of 1,3-dicarbonyl compounds to electron-deficient alkynes

Mikaël Hanédanian, Olivier Loreau, Marcin Sawicki and Frédéric Taran*

*Service de Marquage Moléculaire et de Chimie Bio-organique, DSV/DBJC/SMMCB CEA Saclay 91191 Gif-sur-Yvette, France, Email:

M. Hanédanian, O. Loreau, M. Sawicki, F. Taran, Tetrahedron, 2005, 61, 2287-2294.

DOI: 10.1016/j.tet.2005.01.038


The Bu3P-catalyzed addition of 1,3-diketones, β-keto esters and malonates to alkynoates allows an improved, mild and efficient one pot access to α-(gem-difunctional) cinnamate esters and to conjugated 1,3-diketones.

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Key Words

active methylene compounds

ID: J72-Y2005-2860