Highly enantioselective epoxidation catalysts derived from 1,2-diaminocyclohexane
Eric N. Jacobsen, Wei Zhang, Alexander R. Muci, James R. Ecker and Li Deng
*Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, Email: jacobsenchemistry.harvard.edu
E. N. Jacobsen, W. Zhang, A. R. Muci, J. R. Ecker, L. Deng, J. Am. Chem. Soc., 1991, 113, 7063-7064.
Readily available Mn(III) complexes catalyze alkene epoxidation by bleach in good yields. A highly enantioselective epoxidation catalyst was developed through a logical sequence of ligand modifications.
see article for more examples
Highly Enantioselective, Catalytic Epoxidation of Trisubstituted Olefins
B. D. Brandes, E. N. Jacobsen, J. Org. Chem., 1994, 59, 4378-4380.
Jacobsen Epoxidation, Manganese, Bleach