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Clean and efficient microwave-solvent-free conversion of homochiral amines, α-amino alcohols and α-amino acids to their chiral 2-substituted pyrrole derivatives

Feray Aydogan and Ayhan S. Demir*

*Department of Chemistry, Middle East Technical University, 06531 Ankara, Turkey, Email:

F. Aydogan, A. S. Demir, Tetrahedron, 2005, 61, 3019-3023.

DOI: 10.1016/j.tet.2005.01.120


An efficient, solvent-free, microwave-assisted coupling of chloroenones and amines on the surface of silica gel gave 1,2-disubstituted homochiral pyrroles in good yields.

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reaction pathway

Key Words

Pyrroles, Microwave, Silica gel, Chloroenones

ID: J72-Y2005-2870